Low HR positive breast cancer


Podcast 2021029

Questions: 

  1. Can You explain what is meant by the title „low positive“ luminal breast cancer? 
  2. Is that treshold (<10%) uniform everywhere, in the entire oncology /pathology/ community?
  3. What are the guidelines to follow on this question? 
  4. Can You comment on the two tresholds for defining positive HR status (≥1% vs ≥10%)? 
  5. Is there an implication on therapeutic approach (i.e. how should we be treating these cases, should they receive ET)? Please explain. 
Expert
Giancarlo Pruneri'
Pathologist
National Cancer Institute, IRCCS Foundation
Milan, Italy